模型信息
中文名称:SARS-CoV-2 USA-WA1/2020 滴鼻感染叙利亚仓鼠模型
英文名称:SARS-CoV-2 USA-WA1/2020 intranasally infection Syrian hamsters model
类型:SARS-CoV-2感染动物模型
分级:NA
用途:用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。
研制单位:斯克里普斯研究所@@http://www.scripps.edu/science-and-medicine/research-departments/immunology-and-microbiology/
保存单位:斯克里普斯研究所@@http://www.scripps.edu/science-and-medicine/research-departments/immunology-and-microbiology/
研究背景
暂无介绍
制备方法
SARS-CoV-2-specific human neutralizing mAb CC12.1 isolated from natural infection was injected intraperitoneally into Syrian hamsters at a starting dose of 2 mg/animal (on average 16.5 mg/kg) and subsequent serial 4-fold dilutions. Control animals received 2 mg of a dengue-specific human IgG1 (Den3). Each group of 6 animals were challenged intranasally 12h post-infusion with 1X106 PFU of SARS-CoV-2.
评价验证
暂无介绍
生物安全性
暂无介绍
讨论与结论
暂无介绍
了解中析
实验室仪器
合作客户
