模型信息
中文名称:SARS-CoV-2 nCoV-WA1-2020鼻,口,眼,气管感染恒河猴模型
英文名称:SARS-CoV-2 nCoV-WA1-2020 intranasal, oral, ocular and intratracheal infected rhesus macaque model
类型:SARS-CoV-2感染动物模型
分级:NA
用途:用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。
研制单位:美国国立卫生研究院过敏与传染病研究所病毒学实验室@@http://www.niaid.nih.gov/research/lab-virology-new
保存单位:美国国立卫生研究院过敏与传染病研究所病毒学实验室@@http://www.niaid.nih.gov/research/lab-virology-new
研究背景
暂无介绍
制备方法
Twelve animals were randomly assigned to two groups and inoculated as described previously with a total dose of 2.6x106 TCID50 of SARS-CoV-2 strain nCoV-WA1-2020 via intranasal, oral, ocular and intratracheal routes. Therapeutic treatment was initiated at 12 hours after inoculation with SARS-CoV-2 and continued once daily through 6 days post inoculation (dpi). One group of rhesus macaques was treated with a loading dose of 10mg/kg remdesivir, followed by a daily maintenance dose of 5 mg/kg.
评价验证
暂无介绍
生物安全性
暂无介绍
讨论与结论
呼吸困难
了解中析
实验室仪器
合作客户
