SARS-CoV icGD03滴鼻感染叙利亚仓鼠模型

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更新时间：2025-03-15 /

关键词:SARS-CoV icGD03滴鼻感染叙利亚仓鼠模型 /

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模型信息

中文名称:SARS-CoV icGD03滴鼻感染叙利亚仓鼠模型

英文名称:SARS-CoV icGD03 intranasally infection Syrian golden hamster model

类型:SARS-CoV感染动物模型

分级:NA

用途:用于SARS-CoV感染研究。

研制单位:美国传染病实验室@@http://www.niaid.nih.gov/research/lab-infectious-diseases

保存单位:美国传染病实验室@@http://www.niaid.nih.gov/research/lab-infectious-diseases

研究背景

暂无介绍

制备方法

Primary replication and replication after challenge of SARS-CoV in hamster lungs. Golden Syrian hamsters (50–55 days old) were intranasally inoculated with one of four SARS-CoV strains (A) HK-39 (N= 16), (B) Urbani (N= 16), (C) Frk-1 (N= 16), and (D) icGD03 (N= 12) of SARS-CoV (103 TCID50/hamster). For evaluating viral replication following primary (1◦) infection, four hamsters per strain (three hamsters for icGD03) were sacrificed at day 2 post-infection. For evaluation of protection from secondary (2◦) infection, the remaining hamsters were challenged 28 days after 1◦ infection with the indicated homologous or heterologous strain of SARS-CoV (N= 4 per group; or N= 3/group for icGD03; 103 TCID50/hamster) and sacrificed 2 days later.