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To examine vaccine efficacy in the 288-330+/+/MERS-15 C2 model, mice were vaccinated with Venezuelan equine encephalitis replicon particles (VRPs) expressing MERS-CoV spike protein (spike-VRP), or mock vaccinated with VRPs that express GFP (GFP-VRP), boosted at 4 weeks post prime, and challenged with MERS-15 C2 at 4 weeks post-boost. Mice were administered a prime vaccination of 10μl by footpad injection of either spike-VRP (1×105PFU) or the control GFP-VRP (1×105PFU). Twenty-eight days later mice were boosted with the same dose of their respective VRP strain. At 28 days postboost, all vaccinated mice were challenged with 5×106PFU of MERS-15 clone 2.

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